Repair of UV induced DNA lesions in ribosomal gene chromatin and the role of “Odd” RNA polymerases (I and III)
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- 作者：Romain Charton ; Laetitia Guintini ; Franç ; ois Peyresaubes ; Antonio Conconi ; Antonio.Conconi@usherbrooke.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cyclobutane pyrimidine dimers ; Nucleotide excision repair ; rDNA chromatin ; RNA polymerase I ; RNA polymerase III ; Transcription coupled repair
- 刊名：DNA Repair
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：36
- 期：Complete
- 页码：49-58
- 全文大小：1022 K
文摘
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The proportion of non-nucleosomal and nucleosomal rRNA genes varies during the cell cycle.
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NER is very efficient in the yeast nucleolus; non-nucleosomal rRNA genes are repaired faster than nucleosomal rRNA genes.
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RNA polymerase I-dependent TC-NER is present in yeast but not in higher eukaryotes.
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RNA polymerase I is released at UV induced photoproducts and is replaced by nucleosomes.
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After repair of UV photoproducts, RNA polymerase I elongation is needed to reestablish non-nucleosomal rRNA genes.
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Reversal of CPDs by photolyase is faster in non-nucleosomal then in nucleosomal rDNA chromatin.