Glycation of human γB-crystallin: A biophysical investigation

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• 作者：Susmitnarayan Chaudhury ; Pooja Ghosh ; Sultana Parveen ; Swagata Dasgupta ; ^{swagata@chem.iitkgp.ernet.in}
• 关键词：Diabetic cataract ; Human γB-crystallin ; Glycation
• 刊名：International Journal of Biological Macromolecules
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：96
• 期：Complete
• 页码：392-402
• 全文大小：2127 K
• 卷排序：96

文摘

Uptake of glucose by γB-crystallin increases with incubation time. Oligomerization does not take place upon incubation upto 28 days. Prolonged glycation causes dimerization of the protein. An attachment of a single glucose moiety occurs. Trp residues of the protein are exposed to the solvent on glycation.