Shape-memory starch for resorbable biomedical devices
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- 作者：A. Beilvert ; F. Chaubet ; L. Chaunier ; S. Guilois ; G. Pavon-Djavid ; D. Letourneur ; A. Meddahi-Pell茅 ; D. Lourdin
- 关键词：wb ; wet basis ; RH ; relative humidity ; DMA ; dynamic mechanical analysis ; SMP ; shape-memory polymers ; Tg ; glass transition temperature ; TTrans ; transition temperature
- 刊名：Carbohydrate Polymers
- 出版年：2 January, 2014
- 年：2014
- 卷：99
- 期：Complete
- 页码：242-248
- 全文大小：1502 K
文摘
Shape-memory resorbable materials were obtained by extrusion-cooking of potato starch with 20% glycerol under usual conditions. They presented an efficient shape-memory with a high recovery ratio (Rr > 90%). Their recovery could be triggered at 37 掳C in water. After water immersion at 37 掳C, the modulus decreased from 1 GPa to 2.4 MPa and remained almost constant over 21 days. Gamma-ray sterilization did not have a dramatic impact on their mechanical properties, despite a large decrease of molecular mass analyzed by asymmetrical flow field-flow fractionation coupled with multi-angle laser light scattering (AFFFF-MALLS). Samples implanted in a rat model exhibited normal tissue integration with a low inflammatory response. Thus, as previously investigated in the case of shape-memory synthetic polymers, natural starch, without chemical grafting, can now be considered for manufacturing innovative biodegradable devices for less-invasive surgery.