Reversal of schizophrenia-like symptoms and immune alterations in mice by immunomodulatory drugs

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• 作者：Tatiane da Silva Araú ; jo^a ; ^b ; Adriano Jose Maia Chaves Filho^a ; ^b ; Aline Santos Monte^a ; ^b ; Ana Isabelle de Gó ; is Queiroz^a ; ^b ; Rafaela Carneiro Cordeiro^a ; ^b ; Michel de Jesus Souza Machado^a ; ^b ; Ricardo de Freitas Lima^b ; David Freitas de Lucena^a ; ^b ; Michael Maes^c ; ^d ; ^e ; Danielle Macê ; do^a ; ^b ; ^{daniellesilmacedo@gmail.com} ; ^{danielle.macedo@ufc.br}
• 关键词：Schizophrenia ; Ketamine-induced schizophrenia ; Tryptophan metabolism ; 1-Methyl-D-tryptophan ; Melatonin ; Immunomodulatory drugs
• 刊名：Journal of Psychiatric Research
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：84
• 期：Complete
• 页码：49-58
• 全文大小：1553 K
• 卷排序：84

文摘

Schizophrenia model by repeated ketamine triggers brain neuroimmune alterations. Ketamine increased brain myeloperoxidase activity, IL-4 and IL-6 levels. Ketamine also caused brain oxidative imbalance. 1-methyl-D-tryptophan, an IDO inhibitor, reversed ketamine-induced alterations. Melatonin also reversed behavioral and neuroimmune alterations induced by ketamine.