Genetic variation in the major mitotic checkpoint genes associated with chromosomal aberrations in healthy humans
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- 作者：Asta Fö ; rstia ; b ; a.foersti@dkfz.de" class="auth_mail" title="E-mail the corresponding author ; Christoph Franka ; Bozena Smolkovac ; Alena Kazimirovad ; Magdalena Barancokovad ; Veronika Vymetalkovae ; f ; Michal Kroupaf ; g ; Alessio Naccaratie ; h ; Ludmila Vodickovae ; f ; g ; Janka Buchancovai ; Maria Dusinskaj ; 1 ; Ludovit Musakk ; 1 ; Pavel Vodickae ; f ; 1 ; Kari Hemminkia ; b ; 1
- 关键词：Chromosomal integrity ; Cytogenetics ; Spindle checkpoint ; DNA double-stranded break
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：1 October 2016
- 年：2016
- 卷：380
- 期：2
- 页码：442-446
- 全文大小：327 K
文摘
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Non-specific chromosomal aberrations (CAs) are detected in 1% of in vivo lymphocytes.
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Causes of CAs in population are not known but they may be related to risk of cancer.
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We genotyped 9 variants in mitotic checkpoint related genes on samples from healthy individuals.
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Gene pairs were significantly associated with CAs: PTTG1-ZWILCH and PTTG1-ZWINT.
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MAD2L1 and PTTG1 were the most common partners in any of the two-way interactions.