Sprouty and cancer: The first terms report
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- 作者：Ting Ling Lo ; Chee Wai Fong ; Permeen Yusoff ; Arthur B. Mckie ; Mei-Sze Chua ; Hing Y. Leung and Graeme R. Guy
- 关键词：Sprouty ; Cancer ; Tumour suppressor ; Tumour marker ; Ras/Erk pathway ; Gene deregulation
- 刊名：Cancer Letters
- 出版年：2006
- 出版时间：28 October 2006
- 年：2006
- 卷：242
- 期：2
- 页码：141-150
- 全文大小：377 K
文摘
The Ras/Erk signaling pathway has a central role in development of multi-cellular organisms as well as in signal transmission in the mature individual. Recently, a family of genes, designated Sprouty, induced by the Ras/Erk pathway was found to specify proteins that inhibited the upstream pathway. Being in a position that is likely to control well-characterized oncogene products suggested that the expression levels of the Sprouty genes may be relevant in human carcinogenesis. Early data on the deregulation of Sprouty expression in breast, prostate and liver cancers is discussed along with the notion that some of them might have potential as tumour markers or that the derived proteins may act as tumour suppressors.