Label-free histamine detection with nanofluidic diodes through metal ion displacement mechanism

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• 作者：Mubarak Ali^a ; ^b ; ^M.Ali@gsi.de ; Patricio Ramirez^c ; Ivana Duznovic^a ; Saima Nasir^a ; Salvador Mafe^d ; Wolfgang Ensinger^a ; ^b
• 关键词：Neurotransmitter ; Histamine ; Surface functionalization ; Nanofluidic sensor ; NTA-metal complex
• 刊名：Colloids and Surfaces B: Biointerfaces
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：150
• 期：Complete
• 页码：201-208
• 全文大小：1385 K
• 卷排序：150

文摘

Asymmetric nanopores are prepared via ion track-etching technique. Nanopore surface is functionalized with metal–nitrilotriacetic acid chelates. Nanofluidic sensor recognizes histamine via metal ion displacement mechanism. Histamine sensing is monitored through changes in pore conductance. Poisson-Nernst-Planck model is employed to theoretically describe experiments results.