Synthesis and biological evaluation of deferiprone-resveratrol hybrids as antioxidants, Aβ_1-42 aggregation inhibitors and metal-chelating agents for Alzheimer's disease

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• 作者：Ping Xu^a ; Minkui Zhang^b ; Rong Sheng^b ; ^{shengr@zju.edu.cn} ; Yongmin Ma^a ; ^{yongmin.ma@zcmu.edu.cn}
• 关键词：Resveratrol derivatives ; 3-hydroxypyridin-4-one ; Beta amyloid aggregation ; Antioxidant ; Metal chelator
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：127
• 期：Complete
• 页码：174-186
• 全文大小：3395 K
• 卷排序：127

文摘

22 3-Hydroxypyridin-4-one-resveratrol hybrids were designed. 3i and 4f are good antioxidants, metal-chelating agents and Aβ anti aggregation. SAR between compounds and the Aβ1–42 inhibition activity was outlined.