Linking high resolution mass spectrometry data with exposure and toxicity forecasts to advance high-throughput environmental monitoring
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- 作者：Julia E. Ragera ; Mark J. Strynarb ; Shuang Lianga ; Rebecca L. McMahena ; Ann M. Richardc ; Christopher M. Grulked ; John F. Wambaughc ; Kristin K. Isaacsb ; Richard Judsonc ; Antony J. Williamsc ; Jon R. Sobusb ; sobus.jon@epa.gov" class="auth_mail" title="E-mail the corresponding author
- 关键词：ACToR ; EPA's Aggregated Computational Toxicology Resource ; AHHS ; American Healthy Homes Survey ; AhR ; aryl hydrocarbon receptor ; AR ; androgen receptor ; CASRN ; Chemical Abstract Services Registry Number ; DI ; deionized ; DSSTox ; EPA's Distributed Structure-Searchable Toxicity database ; ERα ; estrogen receptor alpha ; GC ; × ; ; GC&ndash ; TOF/MS ; two-dimensional gas chromatography coupled with time-of-flight mass spectrometry ; HPLC ; high performance liquid chromatograph ; HPV ; high-production v
- 刊名：Environment International
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：88
- 期：Complete
- 页码：269-280
- 全文大小：913 K
文摘
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Exposure data are limited or non-existent for thousands of commercial chemicals.
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We present a novel suspect screening method for characterizing chemicals in dust.
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High-resolution mass spectrometry was used for chemical identification.
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Exposure and toxicity forecasts were used for chemical prioritization.
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This method is suitable for characterizing emerging environmental contaminants.