Influence of artificial sebum on the dermal absorption of chemicals in excised human skin: A proof-of-concept study
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- 作者：Dé ; siré ; e Schneider ; Kathrin Dennerlein ; Thomas Gö ; en ; Karl Heinz Schaller ; Hans Drexler ; Hans.Drexler@fau.de" class="auth_mail" title="E-mail the corresponding author ; Gintautas Korinth
- 关键词：CAS ; chemical abstract service ; CV ; relative coefficient of variation ; GC ; gas chromatography ; KOH ; potassium hydroxide ; LogP ; decadic logarithm of the octanol/water partition coefficient ; NaCl ; sodium chloride ; o/w ; oil in water emulsion ; SD ; standard deviation ; SEM ; standard error of the mean ; w/o ; water in oil emulsion
- 刊名：Toxicology in Vitro
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：33
- 期：Complete
- 页码：23-28
- 全文大小：430 K
文摘
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The influence of artificial sebum and skin cream on the penetration of ethanol and toluene was investigated in human skin.
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Sebum does not enhance the dermal penetration and the intradermal reservoir of the solvents ethanol and toluene.
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Application of skin cream increases the penetration of ethanol.
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The removal of sebum by surgical disinfection seems not to be challenging the use of human skin for ex vivo experiments.