Intranasal delivery of obidoxime to the brain prevents mortality and CNS damage from organophosphate poisoning
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- 作者：Jishnu K.S. Krishnana ; Peethambaran Aruna ; Abhilash P. Appua ; Nivetha Vijayakumara ; Taí ; za H. Figueiredoa ; Maria F.M. Bragaa ; Sudikshya Baskotaa ; Cara H. Olsenb ; Natalia Farkasc ; John Dagatac ; William H. Frey IId ; John R. Moffetta ; Aryan M.A. Namboodiria ; anamboodiri@usuhs.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：2-PAM ; Pralidoxime ; AChE ; Acetylcholinesterase ; BBB ; Blood brain barrier ; CTA ; Chemical threat agent ; FJB ; Fluoro-jade B ; OBD ; Obidoxime ; SE ; Status epilepticus
- 刊名：Neurotoxicology
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：53
- 期：Complete
- 页码：64-73
- 全文大小：3850 K
文摘
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Intranasal (IN) administration of oximes was found to effectively bypass the BBB.
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IN obidoxime (OBD) partially restored brain AChE activity after paraoxon poisoning.
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IN OBD dramatically reduced paraoxon-induced seizures.
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IN OBD fully prevented all neuronal cell loss associated with paraoxon poisoning.
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IN OBD completely prevented the mortality associated with paraoxon poisoning.