Towards efficient and inherently safer continuous reactor alternatives to batch-wise processing of fine chemicals: CSTR nonlinear dynamics analysis of alkylpyridines N-oxidation
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- 作者：Xiaohong Cuia ; b ; M. Sam Mannana ; b ; Benjamin A. Wilhitea ; b ; benjaminwilhite@mail.che.tamu.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Continuous processing ; Fine chemicals and pharmaceuticals ; Reactor modeling ; Nonlinear dynamics ; Productivity ; Process safety
- 刊名：Chemical Engineering Science
- 出版年：2015
- 出版时间：1 December 2015
- 年：2015
- 卷：137
- 期：Complete
- 页码：487-503
- 全文大小：4369 K
文摘
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Reactor analysis for continuous fine chemicals and pharmaceuticals production.
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CSTR model is developed based upon conservation laws and reaction kinetics.
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Operational parameter space separated by steady-state multiplicity and stability.
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Performance metrics and steady-state/dynamic characteristics identify best designs.
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Impact of initial conditions on safe and efficient start-up of the process is investigated.