Synthesis and functionalization of nanoengineered materials using click chemistry

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• 作者：Georgina K. Such ; Angus P.R. Johnston ; Kang Liang ; Frank Caruso ; ^{fcaruso@unimelb.edu.au}
• 关键词：Ab ; antibody ; ATRP ; atom transfer radical polymerization ; Az ; azide ; BSA ; bovine serum albumin ; Cu ; copper ; CuAAC ; copper-catalyzed alkyne-azide cycloaddition ; CB(6) ; cucurbit[6]uril ; CD ; cyclodextrin ; DA ; Diels&ndash ; Alder [4+2] cycloaddition ; DNA ; deoxy
• 刊名：Progress in Polymer Science
• 出版年：2012
• 出版时间：July, 2012
• 年：2012
• 卷：37
• 期：7
• 页码：985-1003
• 全文大小：2209 K

文摘

The synthesis of nanoengineered materials with precise control over material composition, architecture and functionality is integral to advances in diverse fields, including biomedicine. Over the last 10 years, click chemistry has emerged as a prominent and versatile approach to engineer materials with specific properties. Herein, we highlight the application of click chemistry for the synthesis of nanoengineered materials, ranging from ultrathin films to delivery systems such as polymersomes, dendrimers and capsules. In addition, we discuss the use of click chemistry for functionalizing such materials, focusing on modifications aimed at biomedical applications.