Genetic deletion of CRTH2 suppressed MK-801-induced cognitive dysfunction.
Inhibition of CRTH2 by ramatroban suppressed MK-801-induced cognitive dysfunction.
Inhibition of COX-1 by SC-560 suppressed MK-801-induced cognitive dysfunction.
MK-801-induced increase in c-Fos expression in the PVN was abolished in CRTH2−/− mice.
PGD2-CRTH2 signaling is involved in MK-801-induced cognitive dysfunction.