Inhibition of ceramide de novo synthesis by myriocin produces the double effect of reducing pathological inflammation and exerting antifungal activity against A. fumigatus airways infection
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- 作者：Anna Carettia ; Riccardo Torellib ; Federica Perdonic ; Monica Fallenid ; Delfina Tosid ; Aida Zuluetaa ; Josefina Casase ; Maurizio Sanguinettib ; Riccardo Ghidonia ; Elisa Borghic ; Paola Signorellia ; paola.signorelli@unimi.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：BALT ; Bronchial Associated Lymphoid Tissue ; CF ; Cystic Fibrosis ; COPD ; Chronic Obstructive Pulmonary Disease ; CFTR ; CF transmembrane conductance regulator ; CFU ; Colony Forming Units ; Gapdh ; glyceraldehyde-3-phosphate dehydrogenase ; HO1 ; heme oxygenase 1 ; IL-1β ; interleukin-1β ; IL-6 ; interleukin-6 ; IL-8 ; interleukin 8 ; LCMS ; liquid chromatography&ndash ; mass spectrometry ; KC ; keratinocyte chemoattractant (murine homologue of IL8) ; NOD 2 ; nucleotide-binding oligomerization domain-containing protein
- 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：1860
- 期：6
- 页码：1089-1097
- 全文大小：2193 K
文摘
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A. fumigatus infection induces ceramide de novo synthesis and inflammation.
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Myriocin reduces inflammatory mediators induced by A. fumigatus infection.
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Myriocin corrects in Cystic Fibrosis defective killing of A. fumigatus.
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Myriocin upregulates HO1 and NOD2 defensive pathways.
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Myriocin significantly affects fungal lung invasion.