Carotid body removal for treatment of chronic systolic heart failure
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- 作者：Piotr Niewi¨½ski ; Dariusz Janczak ; Artur Rucinski ; Przemyslaw Jazwiec ; Paul A. Sobotka ; Zoar J. Engelman ; Marat Fudim ; Stanislaw Tubek ; Ewa A. Jankowska ; Waldemar Banasiak ; Emma C.J. Hart ; Julian F.R. Paton ; Piotr Ponikowski
- 关键词：Carotid body chemoreceptors ; Surgical resection ; Heart failure ; Autonomic imbalance
- 刊名：International Journal of Cardiology
- 出版年：2013
- 出版时间：3 October, 2013
- 年：2013
- 卷：168
- 期：3
- 页码：2506-2509
- 全文大小：469 K
文摘
Background
Augmented reflex response from peripheral chemoreceptors characterises chronic heart failure (CHF), contributes to autonomic imbalance and exercise intolerance and predicts poor outcome.Methods and results
We present a case of a 56-year-old male patient with ischaemic CHF, who underwent surgical, unilateral carotid body resection to reduce peripheral chemosensitivity. At 2-month and 6-month follow-ups, we document a persistent decrease in peripheral chemosensitivity accompanied by an improvement in exercise capacity, sleep disordered breathing and quality of life. Autonomic balance was favourably affected as evidenced by improved heart rate variability and augmented cardiac baroreflex sensitivity. There were no procedure-related adverse events.
Conclusions
Denervation of a carotid body may offer a clinical strategy to restore autonomic balance and improve morbidity in heart failure ().