Pulmonary Complications of Childhood Cancer Treatment

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• 作者：A. Birgitta Versluys¹ ; ^{a.b.versluys@umcutrecht.nl" class="auth_mail" title="E-mail the corresponding author} ; Dorine Bresters²
• 关键词：Pulmonary complications ; Lung injury ; Childhood cancer survivors ; Chemotherapy late effects ; Irradiation late effects
• 刊名：Paediatric Respiratory Reviews
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：17
• 期：Complete
• 页码：63-70
• 全文大小：1111 K

文摘

Pulmonary complications of childhood cancer treatment are frequently seen. These can lead to adverse sequelae many years after treatment, with important impact on morbidity, quality of life and mortality in childhood cancer survivors. This review addresses the effects of chemotherapy, radiotherapy, surgery and alloimmunity (in haematopoietic cell transplantation) on the lung in children. It highlights the complexity of lung damage and lung disease in relation to growth and development, infections and other external factors. Screening high risk childhood cancer survivors for treatment related late effects, with therapy based screening protocols, using full medical assessment and pulmonary function tests is important. This will lead to recognition of pulmonary sequelae of cancer treatment, early detection of lung damage in survivors and better treatment and prevention.