Magnetic graphene oxide as a carrier for targeted delivery of chemotherapy drugs in cancer therapy

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• 作者：Ya-Shu Huang^a ; Yu-Jen Lu^b ; Jyh-Ping Chen^a ; ^c ; ^d ; ^e ; ^{jpchen@mail.cgu.edu.tw}
• 关键词：Magnetic nanoparticles ; Magnetic graphene oxide ; Doxorubicin ; Irinotecan ; Drug delivery
• 刊名：Journal of Magnetism and Magnetic Materials
• 出版年：2017
• 出版时间：1 April 2017
• 年：2017
• 卷：427
• 期：Complete
• 页码：34-40
• 全文大小：806 K
• 卷排序：427

文摘

mGO was prepared by chemical co-precipitation of Fe3O4 MNP on GO nano-platelets. mGO was further modified by chitosan and mPEG-NHS to synthesize mGOC-PEG. mGOC-PEG showed higher drug loading of doxorubicin (DOX) than irinotecan. mGOC-PEG showed pH-responsive controlled release of chemotherapy drugs. Magnetic targeting enhanced cytotoxicity of mGOC-PEG/DOX toward U87 cancer cells.