Ablation of PPP1R3G reduces glycogen deposition and mitigates high-fat diet induced obesity

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• 作者：Yongxian Zhang¹ ; Jin Gu¹ ; Lin Wang ; Zilong Zhao ; Yi Pan ; Yan Chen ; ^{ychen3@sibs.ac.cn}
• 关键词：Glycogen ; Obesity ; Insulin resistance ; Hepatic steatosis ; Adipocytes
• 刊名：Molecular and Cellular Endocrinology
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：439
• 期：Complete
• 页码：133-140
• 全文大小：1522 K
• 卷排序：439

文摘

Reduced glycogen deposition reduces high-fat diet induced obesity in mice. Increasing glycogen synthesis elevates lipid accumulation in adipocytes. As a glycogen-targeting subunit of PP1, PPP1R3G regulates metabolism in vivo.