Pleiotropic effects of vitamin D in chronic kidney disease
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CKD patients are prone to deficiencies in both 25(OH)D and 1,25(OH)2D.

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Circulating 25(OH)D can convert to 1,25(OH)2D in the extra-renal tissues.

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Native vitamin D improves skeletal quality and quantity in CKD patients.

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Native vitamin D promotes extra-skeletal health in CKD patients.

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The benefit of combination of native and active vitamin D therapy in CKD

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