Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function
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- 作者：David H. Hackos1 ; 6 ; Patrick J. Lupardus2 ; 6 ; Teddy Grand5 ; Yelin Chen1 ; 7 ; Tzu-Ming Wang1 ; Paul Reynen3 ; Amy Gustafson3 ; Heidi J.A. Wallweber2 ; Matthew Volgraf4 ; Benjamin D. Sellers4 ; Jacob B. Schwarz4 ; Pierre Paoletti5 ; Morgan Sheng1 ; Qiang Zhou1 ; 8 ; Jesse E. Hanson1 ; hanson.jesse@gene.com" class="auth_mail" title="E-mail the corresponding author
- 刊名：Neuron
- 出版年：2016
- 出版时间：2 March 2016
- 年：2016
- 卷：89
- 期：5
- 页码：983-999
- 全文大小：3647 K
文摘
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Describe discovery of novel GluN2A-selective NMDAR positive allosteric modulators (PAMs)
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Crystal structures identify a new modulatory site in the GluN2A GluN1 LBD interface
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Distinct PAMs have unique effects on NMDAR biophysical properties
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Distinct PAMs have unique impacts on LTP