Ring-opened tetrahydro-γ-carbolines display cytotoxicity and selectivity with histone deacetylase isoforms

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• 作者：Kunal Nepali^a ; ¹ ; Hsueh-Yun Lee^a ; ¹ ; Mei-Jung Lai^b ; Ritu Ojha^a ; Tung-Yun Wu^c ; Gu-Xian Wu^a ; Mei-Chuan Chen^c ; ^{mcchen1250@tmu.edu.tw} ; Jing-Ping Liou^a ; ^d ; ^{jpl@tmu.edu.tw}
• 关键词：Anticancer agents ; Histone deacetylase inhibitors
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：127
• 期：Complete
• 页码：115-127
• 全文大小：2085 K
• 卷排序：127

文摘

A series of ring-opened tetrahydro-γ-carbolines were designed and synthesized. Five compounds (8, 9, 12, 13, and 18) with potent antiproliferative activity were identified. Compounds 8, 9, 12, 13, and 18 were also potent to inhibit HDAC6 function.