- 作者：Chi-Yu Liu ; Jiaan-Der Wang ; Jen-Ta Yu ; Li-Ching Wang ; Ming-Chih Lin ; Hsiu-Fen Lee ; Po-Yen Chen ; Hsin-Yang Hsieh ; Po-Yu Wang
- 关键词：child ; influenza B virus ; pneumonia
- 刊名：Pediatrics Neonatology
- 出版年：February, 2014
- 年：2014
- 卷：55
- 期：1
- 页码：58-64
- 全文大小：873 K
Background
The clinical significance of influenza B is frequently overlooked, and reports on influenza B pneumonia in children are limited. Therefore, the clinical features of associated complications have rarely been reported. The aim of this study is to evaluate the clinical characteristics in pediatric patients with influenza B virus-associated pneumonia.Methods
From January 2009 to February 2012, 389 consecutive patients under 18 years old with influenza B virus infection were enrolled into the study. Thirty-four patients were defined as the pneumonia group by clinical symptoms and chest X-ray (CXR) findings, and 90 patients who had laboratory data and normal CXR findings were recruited to form the nonpneumonia group.
Results
The age of the patients in the pneumonia group was significantly younger (median of 5.3 vs. 6.6 years). The white blood cell count (median of 7.5 vs. 5.7聽脳聽109聽cells/L) and C-reactive protein level (median of 21.1 vs. 5.7聽mg/L) were higher, but the hemoglobin level was lower (median of 12.6 vs. 13.2聽g/dL) in the pneumonia group. The CXR findings revealed that 29.4% of patients had alveolar consolidation, 32.4% had interstitial infiltration, and 38.2% had ground glass opacity. Two of four patients with pleural effusion had a positive bacteria culture, and both of them died.
Conclusion
Pneumonia should be considered in pediatric patients with influenza B virus infection presenting with younger age, higher white blood cell count, lower hemoglobin, and higher C-reactive protein level. The CXR findings were varied. Patients with pleural effusion and positive bacterial culture may have more severity of clinical outcome.