Synthesis and in vitro antiproliferative evaluation of novel nonsymmetrical disulfides bearing 1,3,4-oxadiazole moiety

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• 作者：Ji-Jun Zhao ; Xue-Feng Wang ; Bao-Lin Li ; Rui-Lian Zhang ; Bo Li ; Yu-Ming Liu ; Cai-Wen Li ; Jin-Biao Liu ; Bao-Quan Chen ; ^{chenbaoquan66@126.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Nonsymmetrical disulfides ; 1 ; 3 ; 4-Oxadiazole ; Antiproliferative activity
• 刊名：Bioorganic & Medicinal Chemistry Letters
• 出版年：2016
• 出版时间：15 September 2016
• 年：2016
• 卷：26
• 期：18
• 页码：4414-4416
• 全文大小：274 K

文摘

A series of novel nonsymmetrical disulfides bearing 1,3,4-oxadiazole moiety were designed, synthesized and evaluated for their in vitro antiproliferative activities against SMMC-7721, Hela and A549 human cancer cell lines by CCK-8 assay. The preliminary bioassay results demonstrated that all tested compounds rong class="boldFont">7arong>–rong class="boldFont">7orong> exhibited antiproliferation with different degrees, and some compounds showed better effects than positive control 5-fluorouracil against various cancer cell lines. Among these compounds, compound rong class="boldFont">7jrong> showed significant antiproliferative activity against SMMC-7721 cells with IC₅₀ value of 3.40 μM. Compound rong class="boldFont">7arong> displayed highly effective biological activity against Hela cells with IC₅₀ value of 4.26 μM. Compound rong class="boldFont">7grong> exhibited the best inhibitory effect against A549 cells with IC₅₀ value of 6.26 μM.