Development of hydroxy-based sphingosine kinase inhibitors and anti-inflammation in dextran sodium sulfate induced colitis in mice
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- 作者：Meiyang Xia ; &dagger ; ; Jun Geb ; &dagger ; ; Xiaojian Wanga ; b ; wangxiaojian@imm.ac.cn" class="auth_mail" title="E-mail the corresponding author ; Chenbin Suna ; Tianqi Liub ; Liang Fangb ; Qiong Xiaoa ; Dali Yina ; b ; yindali@imm.ac.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：SphK ; DSS ; Inflammation ; Colitis
- 刊名：Bioorganic & Medicinal Chemistry
- 出版年：2016
- 出版时间：15 July 2016
- 年：2016
- 卷：24
- 期：14
- 页码：3218-3230
- 全文大小：2384 K
文摘
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We discovered the trihydroxybenzohydrazide scaffold as an SphK inhibitor.
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51 derivatives were synthesized and evaluated for SAR study.
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The most potent compound
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