Mice with Shank3 Mutations Associated with ASD and Schizophrenia Display Both Shared and Distinct Defects
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- 作者：Yang Zhou1 ; 6 ; Tobias Kaiser1 ; Patrí ; cia Monteiro1 ; 4 ; 5 ; Xiangyu Zhang1 ; Marie. S. Van der Goes1 ; Dongqing Wang1 ; Boaz Barak1 ; Menglong Zeng1 ; 7 ; Chenchen Li1 ; 4 ; Congyi Lu1 ; 4 ; Michael Wells1 ; 8 ; Aldo Amaya4 ; Shannon Nguyen4 ; Michael Lewis4 ; Neville Sanjana1 ; 4 ; Yongdi Zhou6 ; Mingjie Zhang7 ; Feng Zhang1 ; 2 ; 3 ; 4 ; Zhanyan Fu1 ; 4 ; Guoping Feng1 ; 2 ; 4 ; fengg@mit.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Neuron
- 出版年：2016
- 出版时间：6 January 2016
- 年：2016
- 卷：89
- 期：1
- 页码：147-162
- 全文大小：2726 K
文摘
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Major psychiatric disorders share many risk genes
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Two mouse lines with ASD-linked and schizophrenia-linked mutations were studied
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Two mutant lines show both shared and distinct synaptic and behavioral phenotypes
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Both developmental and molecular differences were detected in the two mutant lines