Proapoptotic RYBP interacts with FANK1 and induces tumor cell apoptosis through the AP-1 signaling pathway
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- 作者：Wen Maa ; b ; 1 ; Xuan Zhanga ; 1 ; Meng Lia ; Xiaoli Maa ; Bingren Huanga ; Hong Chena ; hchen_222@163.com" class="auth_mail" title="E-mail the corresponding author ; Deng Chena ; chendeng2001@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：RYBP ; Ring1 and YY1 Binding Protein ; FANK1 ; Fibronectin type III and ankyrin repeat domains 1 ; AP-1 ; activator protein 1 ; PRC1 ; polycomb repressive complex 1 ; YY1 ; Yin Yang 1 ; DED ; death effector domain ; DEDD ; DED containing DNA-binding protein ; DISC ; death-inducing signaling complex ; MDM2 ; Mouse double minute 2 homolog ; FNIII ; fibronectin type 3 domain ; ANK ; ankyrin repeat domains
- 刊名：Cellular Signalling
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：28
- 期：8
- 页码：779-787
- 全文大小：1525 K
文摘
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FANK1 is a novel binding partner of proapoptotic RYBP.
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The FNIII domain of FANK1 binds to the Serine/Threonine-rich region of RYBP.
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RYBP probably stabilizes FANK1 by preventing polyubiquitinated FANK1 from proteasomal degradation.
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RYBP induces tumor cell apoptosis through activating FANK-mediated AP-1 signaling pathway.