Activation of IRE1α-XBP1 pathway induces cell proliferation and invasion in colorectal carcinoma
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- 作者：Chun Jina ; 1 ; Zhao Jinb ; 1 ; Nian-zhao Chenc ; Min Lua ; Chang-bao Liua ; Wan-Le Hua ; Chen-guo Zhenga ; zhengchenguo80@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：ER stress ; IRE1α ; Colorectal carcinoma ; Cell proliferation ; Epithelial-to-mesenchymal transition
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：29 January 2016
- 年：2016
- 卷：470
- 期：1
- 页码：75-81
- 全文大小：2205 K
文摘
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IRE1 was determined to be an independent predictor of overall survival in CRC patient.
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IRE1-XBP1 pathway promoted CRC cell proliferation through regulating Cyclin D1 expression.
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IRE1-XBP1 pathway played important role in EMT of CRC cells.