Nitric oxide pathway activity modulation alters the protective effects of (∿Epigallocatechin-3-gallate on reserpine-induced impairment in rats
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- 作者：Cheng-Neng Chena ; 1 ; Kuo-Chi Changb ; 1 ; Rui-Feng Linc ; Mao-Hsien Wangd ; e ; Ruoh-Lan Shihd ; Hsiang-Chien Tsengf ; g ; Hung-Sheng Soungh ; Cheng-Chia Tsaic ; i ; dschang580704@yahoo.com.tw" class="auth_mail" title="E-mail the corresponding author
- 关键词：CAT ; catalase ; Cs ; control group ; DA ; dopamine ; EGCG ; (&minus ; )epigallocatechin-3-gallate ; GSH ; glutathione ; iNOS ; inducible nitric oxide synthase ; L-A ; L-arginine ; L-N ; L-NAME ; LPO ; lipid peroxidation ; MAO ; monoamine oxidase ; NF-κB ; nuclear factor kappa-light-chain-enhancer of activated B cells ; nNOS ; neuronal nitric oxide synthase ; NO ; nitric oxide ; RES ; reserpine ; ROS ; reactive oxygen species ; Rs ; reserpine treatment group ; SOD ; superoxide dismutase ; TBARS ; thiobarbituric acid reactive substa
- 刊名：Behavioural Brain Research
- 出版年：2016
- 出版时间：15 May 2016
- 年：2016
- 卷：305
- 期：Complete
- 页码：198-211
- 全文大小：1982 K
文摘
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EGCG amended reserpine-induced social memory impairment in rats.
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Nitric oxide (NO) pathway activity was increased in reserpine treatment.
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EGCG decreased reserpine-induced NO levels and lipid peroxidation production.
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NO pathway modulators altered EGCG’s protective effects.
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EGCG may have a protective effect when treating cognitive dysfunction.