Brain-derived neurotrophic factor (BDNF) in the rostral anterior cingulate cortex (rACC) contributes to neuropathic spontaneous pain-related aversion via NR2B receptors
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- 作者：Le Zhang1 ; Gongming Wang1 ; Jinben Ma ; Chengxiao Liu ; Xijiang Liu ; Yufeng Zhan ; Mengyuan Zhang ; PhD. ; Zhangmy717@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：BDNF ; brain-derived neurotrophic factor ; CPP ; conditioned place preference ; CTX-B ; cyclotraxin-B ; F-CPA ; formalin-induced conditioned place avoidance ; LTP ; long-term potentiation ; NMDAR ; Nmethyl-d-aspartate receptors ; PFC ; prefrontal cortex ; rACC ; rostral anterior cingulate cortex ; SNI ; spare nerve injury ; TrkB ; tropomyosin receptor kinase B
- 刊名：Brain Research Bulletin
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：127
- 期：Complete
- 页码：56-65
- 全文大小：3245 K
文摘
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BDNF signaling in rACC involves in neuropathic spontaneous pain-related aversion.
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NR2B is an important downstream effector of the BDNF/TrkB signaling pathway.
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A new strategy targeting BDNF in the rACC may be useful for treating pain affect.