The Th17/Treg imbalance in bovine 尾-lactoglobulin-sensitised mice

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• 作者：Ai-Li Li ; Xiang-chen Meng ; Gui-cheng Huo ; Cui-cui Duan ; Quan-ling Zheng ; Dan Li ; Yan Wang
• 刊名：International Dairy Journal
• 出版年：February, 2014
• 年：2014
• 卷：34
• 期：2
• 页码：257-262
• 全文大小：1376 K

文摘

This study investigated whether the Th17/Treg balance was impaired in mice with 尾-lactoglobulin (尾-Lg) allergies. BALB/c mice were intraperitoneally sensitised with 尾-Lg. The Th17/Treg ratios of allergic mice and healthy controls were calculated, and their correlation with specific transcription factors and cytokines were analysed. The results indicated that sensitisation with 尾-Lg led to the development of an allergic response, characterised by inflammatory cell infiltration in the intestine and high levels of IgE in the serum. The frequencies of Th17 cells, Th17-related cytokines and ROR纬t expression were increased, whereas the frequencies of Treg cells, plasma TGF-尾 level and Foxp3 expression were decreased in 尾-Lg-sensitised mice. In addition, the Th17/Treg ratios were positively correlated with the serum concentrations of Th2- and Th17-related cytokines. These results suggest that a Th17/Treg imbalance in combination with an increase in the Th2 cell response may be responsible for the development and progression of 尾-Lg allergy.