- 作者：Kuei-Yueh Cheng ; Wei-Che Lin ; Wen-Neng Chang ; Tzu-Kong Lin ; Nai-Wen Tsai ; Chih-Cheng Huang ; Hung-Chen Wang ; Yung-Cheng Huang ; Hsueh-Wen Chang ; Yu-Jun Lin ; Lian-Hui Lee ; Ben-Chung Cheng ; Chia-Te Kung ; Ya-Ting Chang ; Chih-Min Su ; Yi-Fang Chiang ; Yu-Jih Su ; Cheng-Hsien Lu
- 关键词：Fall-related fractures ; Idiopathic Parkinson's disease ; Risk factors
- 刊名：Parkinsonism and Related Disorders
- 出版年：January, 2014
- 年：2014
- 卷：20
- 期：1
- 页码：88-92
- 全文大小：271 K
Purpose
Fall-related fracture is one of the most disabling features of idiopathic Parkinson's disease (PD). A better understanding of the associated factors is needed to predict PD patients who will require treatment.Methods
This prospective study enrolled 100 adult idiopathic PD patients. Stepwise logistic regressions were used to evaluate the relationships between clinical factors and fall-related fracture.
Results
Falls occurred in 56 PD patients, including 32 with fall-related fractures. The rate of falls in the study period was 2.2聽卤聽1.4 per 18 months. The percentage of osteoporosis was 34% (19/56) and 11% in PD patients with and without falls, respectively. Risk factors associated with fall-related fracture were sex, underlying knee osteoarthritis, mean Unified Parkinson's Disease Rating Scale score, mean Morse fall scale, mean Hoehn and Yahr stage, and exercise habit. By stepwise logistic regression, sex and mean Morse fall scale were independently associated with fall-related fracture. Females had an odds ratio of 3.8 compared to males and the cut-off value of the Morse fall scale for predicting fall-related fracture was 72.5 (sensitivity 72% and specificity 70%).
Discussion
Higher mean Morse fall scales (>72.5) and female sex are associated with higher risk of fall-related fractures. Preventing falls in the high-risk PD group is an important safety issue and highly relevant for their quality of life.