Long noncoding RNA XIST acts as an oncogene in non-small cell lung cancer by epigenetically repressing KLF2 expression
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- 作者：Jing Fanga ; Cheng-Cao Sunb ; chengcaosun@whu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Cheng Gongc ; gongcheng306@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Long noncoding RNA XIST ; KLF2 ; Non-small cell lung cancer (NSCLC) ; Proliferation ; Tumorigenesis
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：16 September 2016
- 年：2016
- 卷：478
- 期：2
- 页码：811-817
- 全文大小：1399 K
文摘
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XIST is up-regulated in human primary NSCLC tissues and cell lines.
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Knockdown of XIST represses NSCLC cell proliferation, migration and invasion, in vitro and vivo.
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XIST represses KLF2 expression via directly binding with EZH2 in NSCLC cells.
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XIST's oncogenic functions are partially through directly binding with EZH2, and then epigenetically repressing KLF2 expression.