Synthesis of 1,2,3-triazole hydrazide derivatives exhibiting anti-phytopathogenic activity

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• 作者：Xing Wang^a ; ^b ; ¹ ; Zhi-Cheng Dai^a ; ^b ; ¹ ; Yong-Fei Chen^a ; ^b ; Ling-Ling Cao^a ; ^b ; Wei Yan^a ; ^b ; Sheng-Kun Li^a ; ^b ; Jian-Xin Wang^a ; ^b ; Zheng-Guang Zhang^a ; ^b ; Yong-Hao Ye^a ; ^b ; ^{yeyh@njau.edu.cn}
• 关键词：1 ; 2 ; 3-Triazole ; Hydrazide ; Antifungal activity ; Fungicide
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2017
• 出版时间：27 January 2017
• 年：2017
• 卷：126
• 期：Complete
• 页码：171-182
• 全文大小：1543 K
• 卷排序：126

文摘

A series of 1,2,3-triazoles hydrazide derivatives was designed and synthesized. The compounds were evaluated for their anti-phytopathogenic activity. Compound 6ad exhibited potent anti-phytopathogenic activity in vitro and in vivo. 1,2,3-triazole hydrazide could be a promising scaffold for fungicide development.