Serine/Threonine Kinase MLK4 Determines Mesenchymal Identity in Glioma Stem Cells in an NF-κB-dependent Manner
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- 作者：Sung-Hak Kim1 ; Ravesanker Ezhilarasan3 ; Emma Phillips4 ; Daniel Gallego-Perez5 ; 6 ; 7 ; 8 ; Amanda Sparks9 ; David Taylor9 ; Katherine Ladner10 ; Takuya Furuta11 ; Hemragul Sabit11 ; Rishi Chhipa12 ; Ju Hwan Cho13 ; Ahmed Mohyeldin9 ; Samuel Beck14 ; Kazuhiko Kurozumi15 ; Toshihiko Kuroiwa16 ; Ryoichi Iwata17 ; Akio Asai17 ; Jonghwan Kim14 ; Erik P. Sulman3 ; Shi-Yuan Cheng18 ; L. James Lee7 ; 8 ; 19 ; Mitsutoshi Nakada11 ; Denis Guttridge10 ; Biplab DasGupta12 ; Violaine Goidts4 ; Krishna P. Bhat20 ; Ichiro Nakano1 ; 2 ; inakano@uabmc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：glioblastoma ; cancer stem cell ; epithelial-to-mesenchymal transition ; proneural-mesenchymal transition
- 刊名：Cancer Cell
- 出版年：2016
- 出版时间：8 February 2016
- 年：2016
- 卷：29
- 期：2
- 页码：201-213
- 全文大小：4910 K
文摘
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Silencing MLK4 attenuates mesenchymal identity in glioma stem cells
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MLK4 activates NF-κB signaling by direct phosphorylation of IKKα
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MLK4 promotes radioresistance in GBM
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MLK4 expression negatively correlates with patient survival of MES but not PN GBM