Intrathecal administration of rapamycin inhibits the phosphorylation of DRG Nav1.8 and attenuates STZ-induced painful diabetic neuropathy in rats
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- 作者：Wan-you He1 ; Bin Zhang1 ; Qing-ming Xiong ; Cheng-xiang Yang ; Wei-cheng Zhao ; Jian He ; Jun Zhou ; Han-bing Wang ; fswhbing@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：STZ ; streptozotocin ; PDN ; painful diabetic neuropathy ; DRG ; dorsal root ganglion ; mTOR ; mammalian target of rapamycin ; S6K ; ribosomal protein S6 kinase ; 4E-BP ; eukaryotic initiation factor 4E (eIF4E) binding protein ; IR ; insulin receptor ; IRS-1 ; insulin receptor substrate-1 ; ERK ; extracellular regulated protein kinases ; i.t. ; intrathecal injection ; MWT ; mechanical withdrawal threshold
- 刊名：Neuroscience Letters
- 出版年：2016
- 出版时间：21 April 2016
- 年：2016
- 卷：619
- 期：Complete
- 页码：21-28
- 全文大小：2082 K
文摘
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A single streptozotocin (STZ) intraperitoneal injection induced diabetes and thus diabetic neuropathy in rats.
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The activation of DRG mTOR increases the phosphorylation of Nav1.8 contributing to hyperalgesia in STZ-induced diabetic rats.
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Intrathecal administration of rapamycin inhibited the phosphorylation of DRG Nav1.8 and attenuates STZ-induced painful diabetic neuropathy in rats.