Synthesis, crystal structure and biological activity of two Mn complexes with 4-acyl pyrazolone derivatives
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- 作者：Yue Lia ; b ; c ; Jing Zhaod ; Chuan-Chuan Hea ; b ; c ; Li Zhanga ; b ; c ; Su-Rong Sund ; Guan-Cheng Xua ; b ; c ; xuguancheng@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Manganese complex ; 4-Acyl pyrazolone derivatives ; Crystal structure ; DNA-binding ; Protein binding ; Antitumor activity
- 刊名：Journal of Inorganic Biochemistry
- 出版年：2015
- 出版时间：September 2015
- 年：2015
- 卷：150
- 期：Complete
- 页码：28-37
- 全文大小：2050 K
文摘
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Two Mn complexes of mononuclear and dinuclear were obtained.
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The interaction of the complex with DNA should be intercalation.
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The protein binding studies confirmed the interactions of the complexes with bovine serum albumin (BSA).
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The complexes possess good anticancer activity.
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Complex 1 inhibit cancer cell's growth by inducing apoptosis.