Cardiac Isoform of Alpha 2 Macroglobulin and Its Reliability as a Cardiac Marker in HIV Patients

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• 作者：Ramasamy Subbiah ; Vipindas Chengat ; Justin D. Clifton ; Andiappan Rathinavel ; Aurelian Bidulescu ; Ramprasath Tharmarajan ; Govindan Sadasivam Selvam
• 关键词：CA2M ; HIV ; Cardiac marker
• 刊名：Heart, Lung and Circulation
• 出版年：2010
• 出版时间：February 2010
• 年：2010
• 卷：19
• 期：2
• 页码：93-95
• 全文大小：111 K

文摘

Background

Cardiac isoform of alpha 2 macroglobulin (CA2M), a serum protein (182000Mr) has been used as a diagnostic molecular marker for cardiac manifestations in HIV and diabetic patients. This study investigates the reliability of CA2M as an early diagnostic marker for cardiac manifestations in HIV patients and factors that could possibly influence their levels.

Methods

A total of 206 serum samples were analysed from HIV patients with cardiac diseases (68), with non-cardiac ailments (48), opportunistic infections (34) and without other co-morbidities (56). The immuno-cross-reactivity between human serum CA2M and anti-rat CA2M antibody was tested and quantified by sandwich enzyme linked immunosorbent assay (ELISA).

Results

The CA2M levels were high in HIV patients with cardiac diseases irrespective of the manifestations. The CA2M levels were not influenced by opportunistic infections, non-cardiac ailments and patient parameters like age, sex, duration of illness, past history of other co-morbidities.

Conclusion

CA2M can be used as a reliable early diagnostic marker in HIV patients with cardiac manifestations. CA2M levels were not influenced by other patient parameters.