Agonist-induced changes in RalA activities allows the prediction of the endocytosis of G protein-coupled receptors
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- 作者：Mei Zhenga ; 1 ; Xiaohan Zhanga ; 1 ; Shuohan Guoa ; Xiaowei Zhanga ; Chengchun Mina ; Seung Hoon Cheonb ; Min-Ho Oakc ; Young Ran Kima ; Kyeong-Man Kima ; kmkim@jnu.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Epsin ; Angiotensin ; LPA ; β-Arrestin ; β-Adrenoceptor
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular Cell Research
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：1863
- 期：1
- 页码：77-90
- 全文大小：2021 K
文摘
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A novel regulatory mechanism for the GPCR endocytosis is proposed.
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The mechanism relies on activity-dependent interaction of GRK2 with active RalA.
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Gβγ-mediated signaling pathway is involved in the regulation of RalA activities.
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The occurrence of GPCR endocytosis can be predicted based on this mechanism.