EphrinB2 Stabilizes Vascularlike Structures Generated by Endothelial Cells and Stem Cells from Apical Papilla
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- 作者：Changyong Yuan ; MDS&lowast ; ; Penglai Wang ; MDS&dagger ; ; Shaoyue Zhu ; BDS&lowast ; ; &dagger ; ; Ting Zou ; MS&lowast ; ; Shuai Wang ; MDS&lowast ; ; Jianguang Xu ; MDS&lowast ; ; Boon Chin Heng ; PhD&lowast ; ; Anibal Diogenes ; PhD&Dagger ; ; Chengfei Zhang ; DDS ; PhD&lowast ; ; zhangcf@hku.hk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Angiogenesis ; ephrinB2 ; human umbilical vein endothelial cells ; stem cells from apical papilla
- 刊名：Journal of Endodontics
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：42
- 期：9
- 页码：1362-1370
- 全文大小：3676 K
文摘
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Coculture of SCAPs and HUVECs yielded significantly longer tubule lengths.
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Delayed addition of SCAPs to HUVECs resulted in longer-persisting vessel structure.
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EphrinB2 phosphorylation started at 0.5 hours of coculture and peaked at 1 hour.
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Enhanced migration of HUVECs by SCAPs could be inhibited by ephrinB2-Fc.
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EphrinB2-Fc stabilized vascularlike structures compared to the control group.
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EphrinB2 plays an important role in stabilization of vascularlike structures.