Targeted p21WAF1/CIP1 activation by miR-1236 inhibits cell proliferation and correlates with favorable survival in renal cell carcinoma
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- 作者：Chenghe Wang ; M.D. ; Ph.D.a ; b ; 1 ; Kun Tang ; M.D. ; Ph.D.a ; b ; 1 ; Zhen Li ; Ph.D.c ; Zhong Chen ; M.D. ; Ph.D.a ; b ; chenzhongtongji@126.com" class="auth_mail" title="E-mail the corresponding author ; Hua Xu ; Ph.D.a ; b ; xuhuawhu@163.com" class="auth_mail" title="E-mail the corresponding author ; Zhangqun Ye ; M.D. ; Ph.D.a ; b
- 关键词：p21 (Cip1/Waf1) ; miR-1236 ; RNAa ; Prognosis ; Proliferation ; Renal cell carcinoma
- 刊名：Urologic Oncology: Seminars and Original Investigations
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：34
- 期：2
- 页码：59.e23-59.e34
- 全文大小：1610 K
文摘
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Low expression of miR-1236 and p21 acted as independent prognostic factors for poor clinical survival in patients with RCC.
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miR-1236 Inhibited cell proliferation and decreased CDK4/6 and cyclin D1 expression.
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miR-1236 Can effectively activate p21 expression by directly targeting the promoter.
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miR-1236 Markedly inhibits RCC cell proliferation and survival by activating p21.