Nemo like kinase negatively regulates NF-魏B activation and聽coelomocytes apoptosis in Apostichopus japonicus
详细信息 查看全文
- 作者：Zhimeng Lv ; Chenghua Li ; lichenghua@nbu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; chli@yic.ac.cn" class="auth_mail" title="E-mail the corresponding author ; Weiwei Zhang ; Chunua Jin ; Yina Shao ; Duan Xuemei ; Han Qingxi
- 关键词：NNemo-like kinase ; Apostichopus japonicus ; NF-魏B ; Cell apoptosis ; RNAi
- 刊名：Developmental & Comparative Immunology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：54
- 期：1
- 页码：109-115
- 全文大小：1511 K
文摘
- •
First Nemo-like kinase (NLK) gene were identified in Apostichopus japonicus.
- •
AjNLK were ubiquitously expressed in all examined tissues.
- •
AjNLK mRNA in coelomocytes was depressed after Vibrio splendidus or LPS exposure.
- •
The expression level of Ajp105 and AjI魏B were tightly correlated with AjNLK.
- •
AjNLK could negatively regulate coelomocytes apoptosis in vitro.