JNK1 inhibits transcriptional and pro-apoptotic activity of TAp63γ
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- 作者：Ji Chena ; b ; 1 ; Hua Shic ; 1 ; Jin Qid ; 1 ; Dingyi Liub ; Zemin Yanga ; Chenghua Lia ; lichenghua@scu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：c-Jun N-terminal kinase 1 ; TAp63γ ; Transactivity ; Apoptosis
- 刊名：FEBS Letters
- 出版年：2015
- 出版时间：30 November 2015
- 年：2015
- 卷：589
- 期：23
- 页码：3686-3690
- 全文大小：905 K
文摘
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JNK1 physically interacts with transactivation domain of TAp63γ.
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Overexpression of JNK1 inhibits TAp63γ transactivity.
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Ser12 in TAp63γ is critical for JNK1-mediated trans-inhibition.
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Inhibition or knockdown of JNK1 increases TAp63γ transactivity.
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JNK1 inhibits TAp63γ-mediated cell apoptosis.