Elevated matrix metalloproteinase expression after stent implantation is associated with restenosis

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• 作者：Junbo Ge ; Chengxing Shen ; Chun Liang ; Lianglong Chen ; Juying Qian ; Haozhu Chen
• 关键词：Extracellular matrix ; Coronary stenting ; Restenosis
• 刊名：International Journal of Cardiology
• 出版年：2006
• 出版时间：10 September 2006
• 年：2006
• 卷：112
• 期：1
• 页码：85-90
• 全文大小：172 K

文摘

Objective

Matrix metalloproteinases (MMPs) play a key role in intimal growth and is responsible for ventricular remodeling after stent implantation. However, little is known about the relationship between early MMPs expression post-stent implantation and follow-up restenosis.

Methods

We investigated the serial changes of serum MMP-9, MMP-2 and tissue inhibitor of metalloproteinase-1 (TIMP-1) in 16 control subjects with normal coronary angiography (control) and 40 patients before and on the 1st, 3rd and 7th day after uncomplicated stent implantation. Follow-up angiography was performed at 6 months after stent implantation.

Results

Serum MMP-2 level was higher in patients with restenosis on the 1st day post-stent implantation and returned to pre-operation level thereafter. Serum MMP-9 levels consistently increased in patients with restenosis up to 7th day post-stent implantation; MMP-9 levels in the 1st, 3rd and 7th day after stent implantation were positively correlated to the late loss index 6 months after stent implantation.

Conclusions

Increased serum MMP-9 level is associated with increased risk of restenosis post-stent implantation.