Reference values for serum levels of insulin-like growth factor-I and insulin-like growth factor binding protein-3 in Korean children and adolescents

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• 作者：Sei Eun Hyun^a ; Byung Churl Lee^b ; Byung Kyu Suh^b ; So Chung Chung^c ; Cheol Woo Ko^d ; Heung Sik Kim^e ; Kee Hyoung Lee^f ; Sei Won Yang^g ; Choong Ho Shin^g ; Jin Soon Hwang^h ; Duk Hee Kim^a ; Baek Keun Limⁱ ; Jong Duck Kim^j ; Han-Wook Yoo^k ; Hye Soon Kim^l ; Woo Yeong Chung^m ; Mi Jung Park^m ; Young Jong Wooⁿ ; Chan Jong Kimⁿ ; Dae-Yeol Lee^o ; Eun Young Kim^p ; Jin Ho Choi^q ; Heon Seok Han^r ; Il Tae Hwang^s ; Ho-Seong Kim^a ; ^{kimho@yuhs.ac}
• 关键词：IGF-I ; IGFBP-3 ; Korean ; Child ; Adolescent
• 刊名：Clinical Biochemistry
• 出版年：2012
• 出版时间：January 2012
• 年：2012
• 卷：45
• 期：1-2
• 页码：16-21
• 全文大小：488 K

文摘

Objective

Measurements of serum insulin-like growth factor-I (IGF-I) and IGF binding protein-3 (IGFBP-3) are utilized in the diagnostic work-up and clinical management of children with growth disorders. We designed this study to establish the reference values of serum IGF-I and IGFBP-3 levels according to age, sex and pubertal stage in Korean children and adolescents.

Methods

For the study, 1378 healthy Korean children and adolescents aged 0 to 17 years (722 boys, 656 girls) were randomly selected. Blood samples were collected, and the stored sera were assayed for IGF-I and IGFBP-3 using immunoradiometric assay (IRMA, Immunotech). The R 2.8.1 program (Bell Laboratories) was used to generate reference percentile curves for IGF-I and IGFBP-3 according to age, sex, and pubertal stage

Results

Serum IGFBP-3 level was higher in girls compared to that in boys of the same ages throughout the pubertal period, whereas IGF-I was only higher for girls younger than 13 years of age. Serum levels of IGF-I and IGFBP-3 increased steadily with age in the prepubertal stage, followed by a progressive decline thereafter. Peak levels of serum IGF-I and IGFBP-3 were observed two years earlier in girls compared to those in boys (13 vs. 15 years of age, respectively). Serum IGF-I and IGFBP-3 concentrations were highest at Tanner stage IV in boys and girls, with a subsequent decline.

Conclusions

Our reference value model based on age, sex, and pubertal stage can improve the diagnostic utility of IGF-1 and IGFBP-3 levels in the evaluation and management of Korean children and adolescents with growth disorders.