Forensic and population genetic characteristics of 62 X chromosome SNPs revealed by multiplex PCR and MALDI-TOF mass spectrometry genotyping in 4 North Eurasian populations
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- 作者：Vadim Stepanova ; b ; vadim.stepanov@medgenetics.ru" class="auth_mail" title="E-mail the corresponding author ; Ksenyia Vagaitsevaa ; b ; Vladimir Kharkova ; b ; Anastasia Cherednichenkoa ; Anna Bocharovaa ; Galina Berezinac ; Gulnara Svyatovac
- 关键词：X chromosome ; Single nucleotide polymorphisms ; Multiplex genotyping ; MALDI-TOF mass spectrometry ; Native North Eurasian populations
- 刊名：Legal Medicine
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：18
- 期：Complete
- 页码：66-71
- 全文大小：593 K
文摘
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We developed a multiplex panel of 62 X chromosome SNPs (XSNPid) genotyped by multi-locus PCR and MALDI-TOF mass spectrometry.
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Four native North Eurasian populations (Buryat, Kazakh, Khakas and Khanty) demonstrate high level of genetic diversity and relatively low but significant level of genetic differentiation.
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The XSNPid panel exhibits a very high discriminating power in each population.