“Presynaptic silence” may be golden

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• 作者：Voronin ; Leon L. ; Cherubini ; Enrico
• 关键词：Presynaptically silent synapses ; Postsynaptically silent synapses ; LTP ; Development ; Probability of glutamate release ; Insertion of new AMPA receptors
• 刊名：Neuropharmacology
• 出版年：2003
• 出版时间：September, 2003
• 年：2003
• 卷：45
• 期：4
• 页码：439-449
• 全文大小：476 K

文摘

Conversion of “silent” synapses into active ones is a likely mechanism for long-term potentiation (LTP), an experimental paradigm for studying information storage. A widely accepted mechanism that has been suggested for synaptic silence is that functional AMPA glutamate receptors (AMPARs) are absent on the subsynaptic membrane. Evidence is presented here that in many cases the cause of apparent “silence” is presynaptic and due to a low level of glutamate release. Increased transmitter release is crucial for early LTP maintenance. Delayed modifications in postsynaptic receptors matched with transmitter release changes underlie structural alterations associated with late LTP phases.