Creatine biosynthesis and transport in health and disease
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- 作者：Marie Joncquel-Chevalier Curta ; b ; Pia-Manuela Voicuc ; Monique Fontainea ; b ; Anne-Fré ; dé ; rique Desseina ; Nicole Porcheta ; h ; Karine Mention-Mulliezb ; d ; Dries Dobbelaereb ; d ; Gustavo Soto-Arese ; David Cheillanf ; g ; Joseph Vamecqa ; b ; h ; joseph.vamecq@inserm.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Creatine ; AGAT ; GAMT ; SLC6A8 ; CRTR ; AMP activated protein kinase ; Secondary creatine disorders
- 刊名：Biochimie
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：119
- 期：Complete
- 页码：146-165
- 全文大小：2522 K
文摘
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Primary creatine disorders highlight a role of creatine in brain physiology.
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SLC6A8 takes part in creatine transport and re-uptake but also in biosynthesis.
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Secondary creatine defects stress dependence of creatine metabolism on many pathways.
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The high dependence on multiple metabolic pathways supports creatine as a cell sensor.
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Creatine is a potential sensor of cell methylation and energy status.