Capillary-liquid chromatography (CLC) and nano-LC in food analysis
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- 作者：Chiara Fanali ; Laura Dugo ; Paola Dugo ; Luigi Mondello
- 关键词：AA ; Amino acid ; APCI ; Atmospheric pressure chemical ionization ; CLC ; Capillary-liquid chromatography ; EI ; Electronic impact ; ESI ; Electrospray ionization ; FITC ; Fluorescein isothiocyanate ; HILIC ; Hydrophilic interaction liquid chromatography ; LLE ; Liquid-liquid extraction ; MS ; Mass spectrometry ; MAE ; Microwave-assisted extraction ; MIP ; Molecularly-imprinted polymer ; nano-LC ; Nano-liquid chromatography ; OT ; Open tubular ; QuEChERS ; Quick ; Easy ; Cheap ; Effective ; Rugged ; Safe ; SPE ; Solid-phase extr
- 刊名：TrAC Trends in Analytical Chemistry
- 出版年：December, 2013
- 年：2013
- 卷：52
- 期：Complete
- 页码：226-238
- 全文大小：1463 K
文摘
Capillary-liquid chromatography (CLC) and nano-LC are miniaturized techniques with great potential in the analytical field. They have been applied in different areas - pharmaceuticals, biomedicine, environment and recently food and agrochemicals. CLC and nano-LC separations are carried out in capillaries of narrow internal diameter (10-320 渭m) containing selected stationary phases. Short analysis time, high mass sensitivity, minute volumes of samples and mobile phases, and easy coupling with mass spectrometry are the main features. We review the general principles of the two miniaturized techniques, their advantages over conventional LC, and the most important applications in food analysis.