Central inhibitory effects on feeding induced by the adipo-myokine irisin

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• 作者：Claudio Ferrante ^{cferrante@unich.it" class="auth_mail" title="E-mail the corresponding author} ; Giustino Orlando ^{gorlando@unich.it" class="auth_mail" title="E-mail the corresponding author} ; Lucia Recinella ^{lrecinella@unich.it" class="auth_mail" title="E-mail the corresponding author} ; Sheila Leone ^{s.leone@unich.it" class="auth_mail" title="E-mail the corresponding author} ; Annalisa Chiavaroli ^{achiavaroli@unich.it" class="auth_mail" title="E-mail the corresponding author} ; Chiara Di Nisio ^{c.dinisio@unich.it" class="auth_mail" title="E-mail the corresponding author} ; Rugia Shohreh ^{rugia82@hotmail.it" class="auth_mail" title="E-mail the corresponding author} ; Fabio Manippa ^{fabiomanippa@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Adriana Ricciuti ^{adrianaricciuti@virgilio.it" class="auth_mail" title="E-mail the corresponding author} ; Michele Vacca ^{mvacca@unich.it" class="auth_mail" title="E-mail the corresponding author} ; Luigi Brunetti ; ^{brunetti@unich.it" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Irisin ; DA ; NE ; CART ; Orexin-A ; POMC
• 刊名：European Journal of Pharmacology
• 出版年：2016
• 出版时间：15 November 2016
• 年：2016
• 卷：791
• 期：Complete
• 页码：389-394
• 全文大小：865 K

文摘

Irisin, the soluble secreted form of fibronectin type III domain containing 5 (FNDC5)-cleaved product, is a recently identified adipo-myokine that has been indicated as a possible link between physical exercise and energetic homeostasis. The co-localization of irisin with neuropeptide Y in hypothalamic sections of paraventricular nucleus, which receives NPY/AgRP projections from the arcuate nucleus, suggests a possible role of irisin in the central regulation of energy balance. In this context, in the present work we studied the effects of intra-hypothalamic irisin (1 μl, 50–200 nmol/l) administration on feeding and orexigenic [agouti-related peptide (AgRP), neuropeptide Y (NPY) and orexin-A] and anorexigenic [cocaine and amphetamine-regulated transcript (CART) and proopiomelanocortin (POMC)] peptides in male Sprague-Dawley rats. Furthermore, we evaluated the effects of irisin on hypothalamic dopamine (DA), norepinephrine (NE) and serotonin (5-hydroxytryptamine, 5-HT) concentrations and plasma NE levels. Compared to vehicle, irisin injected rats showed decreased food intake, possibly mediated by stimulated CART and POMC and inhibited DA, NE and orexin-A, in the hypothalamus. We also found increased plasma NE levels, supporting a role for sympathetic nervous system stimulation in mediating increased oxygen consumption by irisin.